Yes they'll handle a kicker 2500.1 no problem as long as you aren't clipping. they're rated at 1000 RMS 2000 Max, but I had my 15 running on a 2400 watt RMS amp at one point without any issues. as for the box, it'll work too but its a bit small. I had a 5ft^3 box just for one 15, but that was Memphis's optimal ported box size. I don't have their recommended box specs anymore, but I think 6.7ft^3 will be fine.