80hz is fine for a freq response general start point but you need to first look up the CTX model and check the freq response zone of the speakers. Many mids don’t start at 80hz and may start response around 100hz. Even though I think you have other issues more pressing, if your mids were not designed to recreate a freq that low you may be out of luck having your current mids sound the way you want them to.
What type of vehicle is this set up in? Is the sub in the same airspace as your mids? (all in the cabin or sub in the trunk?) What is the cut off freq of your sub? You said it is tuned low but how low are we talking?(not box tuning but crossover wise) How are you crossing the mids over? Amp high pass? What are your settings adjusted to?
Other than my questions keep in mind that you have only 2- 6.5's competing with an 18 on your human ears. Sounds properties make perfect sense but almost all studies have been recorded in controlled environments (ideal space, temp, constant controlled power etc) and don’t always work in theory inside a terrible acoustical environment. (all cars) Have you listened to the mids with the sub off? If so, are they responding to the midbass freq or just sound like shit on the good midbass notes? If they sound good you may need additional mids to achieve a complete sound.