as a cabinet maker of 12 years i am one of the very few here who are qualified to even think about your question.....
id say go for it. the enclosure will have a far superior resonance and tonal response than mdf, and be stronger as well, as long as you do your joints correctly. i am very interested in seeing what you come up with. for a stiff enclosure, hickory would be optimal. for tonal response, poplar is great.
alright so hickory and poplar any other hard woods that are great to build boxes with i already have some ash and cherry. how are those two?
ash has a great resonance to it, which is why its used in a majority of the stringed instruments produced these days. hickory isnt so much of a tone wood, its just fuckin' strong.
alright i think im gonna go with the ash but how is cherry as far as resonance and tonal response go